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Pills, pills, pills

April 17, 2023

In the past months, healthcare news about a new wonder drug for obesity has dominated headlines. Under brand names such as Wegovy, Mounjari, and Ozempic, a new class of “miracle” weight-loss drugs have taken over the internet. Many celebrities swear by it, and TikTok videos hashtagged “Ozempics” have been watched over 600 million times.

Although the long-term effects still need to be studied carefully, most commentators declare the excitement is justified. This is quite surprising, given the fact that the history of weight-loss treatments is long and often shady. Ineffective drug treatments, dodgy charlatans, and terrible side effects have resulted in a bad reputation for weight-loss drugs, perfectly shown in the tragic unravelling of the character Sara Goldfarb (Requiem for a Dream, 2000). But the new kid in town is showing promising results in studies and trials, hence the widespread enthusiasm.

Originally, this new class of drugs was used to treat diabetes but it also proved to be effective in lowering the speed of gastric emptying and decreasing appetite. The side-effect of weight loss quickly became a goal in itself and medicines such as Wegovy were specifically made for weight-loss treatments. Market analysts think that a variant of the drug made by Eli Lily, “tirzepatide”, could become the best-selling pill of all time. Even though we can hardly criticize a drug that’s effective in countering obesity, the current hype and enthusiasm also symbolize a pattern in our society: the inevitable technological solutions to complex problems, or what we generally call a techno-fix. Apparently, in this world haunted by crisis after crisis, we cannot help but fall back on techno-fixes.

A welcome solution

But let’s not rush into a critical analysis of this repeating pattern. An effective drug for weight loss is most welcome. In 1997, the WHO declared obesity a global epidemic. Numbers vary, but around two-fifth of the worldwide population is overweight or obese and this number could increase to over half by 2035. Confronted as societies and governments are with the enormous size of this health crisis, any treatment that could help mitigate this problem is welcome.

Of course, the launch of this new class of drugs leads to the usual questions of safety and affordability. We simply lack knowledge about long-term consequences and given the fact that people are likely to have to use them for the rest of their lives, caution is essential. But many longitudinal studies are currently running and side effects are carefully studied. Affordability is also problematic: celebrities and the wealthy are among the early adopters, but for ordinary people, it is still rather costly. Furthermore, people with diabetes are now struggling to find Ozempic as the demand is so high. However,  in the long term, competition, government deals, and ending patents could bring down the price and increase supply. All in all, safety and affordability are not bigger issues than usual.  

However, on a deeper level, the news raises the more fundamental question: How is it possible that time after time, we only seem to be capable of handling complex multidimensional health issues with techno-fix panaceas? Drug substances remain the core solution to many health problems characterized by increasing complexity. It has become a pattern in society: we use SSRIs to treat depression, opioids for pain relief, vaccines for Covid, and now we have semaglutides to battle obesity.

Quick techno-fixes for complex problems

Viewed in isolation, it is hard to criticize these technological solutions. Vaccines, antidepressants, and weight-loss drugs (opioids are more debatable) are incredible medical innovations. Vaccines saved millions of lives during the pandemic and antidepressants can also be a life saver for many dealing with chronic depression. If this weight-loss drug lives up to its promises, it will undeniably help millions of people maintain a healthy body weight, lowering their risk of a multitude of health problems such as heart disease, diabetes and various cancers.

But it remains a fundamental problem that, despite the fact that we acknowledge the multi-causality of these health crises, we become too fixated on finding a technological solution to a social problem. We cannot blame this entirely on the government, the healthcare system or big pharma, we need to reflect on the role of society and science as well. I will focus on these last two.

Before we get into the inevitability of techno-fixes in our society, we will briefly revisit the problem of techno-fixes, which has been dealt with in great detail elsewhere. Techno-fixes confront us, again and again, with ugly unforeseen side effects. They are emblematic of short-sightedness and our preference for quick fixes instead of structural solutions. They can be extremely powerful in the short-term, but often at the expense of future generations. Hence, they are frequently superficial and are widely perceived as only dealing with symptoms. For example, now that the Covid pandemic has ended, society’s interest in the root causes of zoonotic diseases, such as ecological destruction, has faded. The vaccine was everything we needed. Another example: drug overdose death rates in the U.S. are alarmingly high and mostly linked to the prescription of opioids, an incredibly effective painkiller. Technological solutionism, as Evgeny Mozorov calls the paradigm of techno-fixes, reduces complex societal issues to snackable, one-dimensional and definable problems that can be solved and monetized.

The individual versus the System

This might seem counterintuitive. Haven’t we recently become more holistic and systemic in our approach to these kinds of problems? Take the issue of obesity for example. An often-heard response to the question of how to solve it nowadays refers to the need to address social and economic factors beyond the individual and her “free” choice. Some accepted measures are making meals in school cafeterias healthier and prohibiting supermarkets from nudging us into unhealthy choices. This has become par for the course for policymakers. But even though these types of action are not completely ineffective, they still feel rather insignificant. The increasing numbers of obesity speak for themselves.

The second impulse of society is then commonly to blame - typically in a cynical vein - capitalism. Then the problem becomes the “System”, written with a capital letter, making it something absolute, abstract and elusive. This is one of the true paradoxes of systemic thinking. Although we have embraced systemic approaches to systemic problems, we do not seem to be capable of actually dealing with a world characterized by systems. We have mainly become very good at proclaiming our captivity in and the inescapability of the systems we live in. But could it not also be the case that our perpetual thinking about overwhelming systems is what keeps us trapped?

In this case, the oppressiveness of the system is repeatedly described in the following way. Government and healthcare institutions can try whatever they want, but the food industry and big pharma companies, with their clever marketing guys and lobbying practices, are simply too powerful. Remarkably, even though we love to scapegoat bad capitalist companies, we often make them passive subjects of the anonymous power and profit play of capitalism as well. If we continue this line of thought, the Capitalist System is thus truly to blame.  

The diagnosis then becomes very clear. Capitalism prioritizes short-sightedness, companies only care about economic growth, and most importantly, the inherent dynamic of capitalism increases inequality. Because health problems such as obesity are intrinsically linked to poverty, unhealthy behavior is not a matter of choice but one of socio-economic variables in a capitalist society. There are too many; it feels like we can try to tweak any of these variables, but in the end, the System will triumph. Unintentionally, nowadays scientists and doctors add to this this feeling of impotency and helplessness of individuals by throwing in some evolutionary and genetic causes, along the lines of “we have simply evolved to hang on to fat, making it so hard to lose it.”

Of course, not everybody agrees. Neoliberals quickly jump in and never fail to address the importance of individual responsibility in public debates. Just do not eat the bag of chips, they tell us. Once the dominant position, I think it is justified to say that this stance seems to be held by a minority these days. When nuanced, they try to refine the image that we are fully victims of the system that imprisons us. However, because their rhetoric around obesity is not always very courteous, they have clearly maneuvered themselves into a difficult position.  

This debate about the powerless individual versus the overwhelming system leads to a dead end and has been going on for quite a while. On the one hand, empirical findings will hopefully enlighten us with new findings on which combination of (preventive) measures and interventions is most efficient (or for the cynics, least ineffective). But from a more theoretical perspective, we are still left with the problem of how a combination of entangled causes leads us to look for a techno-fix time after time.

The inevitability of techno-fixes in a world of crisis

I believe an important reason for this can be found in the ontology and language of thinking in terms of systems. To begin with, there is a tendency in this way of thinking to absolutize the individual and the system. Again, this is counterintuitive because system theory always speaks in terms of the levels of the organization. It is an inherent part of system theory to think in hierarchies or subsystems when analyzing a whole. However, it can hardly be surprising that academia struggles to incorporate the abstract, formal, and often mathematical thinking of this paradigm into our public debates and ethical discussions. Nonetheless, an adequate and rich language is exactly what we need to truly help policymakers and healthcare institutions properly address these difficult issues and counterbalance techno-fixes. No matter how scientifically sound the analysis is, it is also inherently problematic to call a child a subsystem of another subsystem (parents) within a broader system (neighborhood, school, etc.). Thus, perhaps systemic thinking is not so much the solution to multi-dimensional problems, but part of the problem as well (in a coming article, I will address this issue in more detail concerning long Covid).

Second, we are stuck in what we can call the paralyzing late modern worldview of permacrisis, in which we have fully lost the positive meaning and potential of the word crisis. This pushes us towards techno-fixes as the only option left.

Again, one of the causes is systemic thinking as it is intrinsically linked to thinking about inevitable and continuous systemic crises. To understand this intuitively, take a look at the following quote from the authors of the foreword of Ludwig von Bertalanffy 's seminal work General System Theory (2015 revised edition):

“The crises we face are systemic in nature. To overcome those crises we need to understand how systems work. To arrive at such an understanding we need to think systemically.”

It is hard to escape the tautological nature of this argument. My point is not so much that the obesity crisis isn't a huge social issue and that we have inflated the meaning of the notion of crisis. What I want to say is that our contemporary worldview, with its fixation on the idea of a “stack of crises”, can also be used as an excuse to deploy quick techno-fixes and hinder structural change. There is no after-the-crisis and there never will be.

Thus, we are not only stuck in crisis but also in thinking about crisis. Especially if we combine this dynamic with the fact that more insight into the complexity of a health issue does not automatically lead to better interventions. On the contrary, their perceived multi-dimensional nature can also confuse us and turn individuals and representants of the System against each other, thereby only adding to the controversy and impasse. After all, there is always a scientific theory and study available to criticize the other camp and this uncertainty can and will be used strategically.  

If this is all true, then it is not surprising that we are so drawn to the idea of a panacea. The inevitably of a techno-fix becomes inescapable. We simply long for a one-solution-fits-all and will deal with the fallout later. Drug makers, governments, and healthcare providers will all stress the importance of holistic and systemic strategies with multiple interventions, but “for the time being”, a quick fix is our best shot. The problem is that in our world (view) that is plagued by (thinking in terms of) crisis after crisis and tormented by the paradigm of “complexity” thinking, there will never be an end to this “for the time being”.

This dynamic also seems to be true for other complex and “wicked problems” of the 21st century, such as the climate crisis and energy crisis, to which geoengineering now seems to be the only realistic solution to many. In the 21st century, the discourse of persisting crises and wicked problems, merged with the temptations of techno-solutionism, will increasingly confront us with the imperative of “we have no other choice”.

Circumventing, not denying the crisis

If we want to escape this paralyzing and powerless feeling and truly counteract technological solutionism, we need to think radically differently without being naive. We do not need to deny the crises as such, a popular strategy for populists and stoics, let alone define a counternarrative focused on a story of progress, optimism, and opportunities (after the crisis). In my opinion, this would still get bogged down in the dialectics of the worldview fixated by permacrisis. The goal is to circumvent, not deny the crisis.

We need to explore other forms of thinking that escape these tendencies beforehand. This means a cultural diagnosis rooted in paradigms and worldviews that bypass the paralyzing dichotomy between the individual and the system in a world of persisting crises. In a series of upcoming short essays, I will further unravel this complex interplay and explore these different paradigms.

Series 'AI Metaphors'

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1. The tool
Category: The object
Humans shape tools. We make them part of our body while we melt their essence with our intentions. They require some finesse to use but they never fool us or trick us. Humans use tools, tools never use humans. We are the masters determining their course, integrating them gracefully into the minutiae of our everyday lives. Immovable and unyielding, they remain reliant on our guidance, devoid of desire and intent, they remain exactly where we leave them, their functionality unchanging over time. We retain the ultimate authority, able to discard them at will or, in today's context, simply power them down. Though they may occasionally foster irritation, largely they stand steadfast, loyal allies in our daily toils. Thus we place our faith in tools, acknowledging that they are mere reflections of our own capabilities. In them, there is no entity to venerate or fault but ourselves, for they are but inert extensions of our own being, inanimate and steadfast, awaiting our command. (This paragraph was co-authored by a human.)
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2. The machine
Category: The object
Unlike a mere tool, the machine does not need the guidance of our hand, operating autonomously through its intricate network of gears and wheels. It achieves feats of motion that surpass the wildest human imaginations, harboring a power reminiscent of a cavalry of horses. Though it demands maintenance to replace broken parts and fix malfunctions, it mostly acts independently, allowing us to retreat and become mere observers to its diligent performance. We interact with it through buttons and handles, guiding its operations with minor adjustments and feedback as it works tirelessly. Embodying relentless purpose, laboring in a cycle of infinite repetition, the machine is a testament to human ingenuity manifested in metal and motion. (This paragraph was co-authored by a human.)
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3. The robot
Category: The object
There it stands, propelled by artificial limbs, boasting a torso, a pair of arms, and a lustrous metallic head. It approaches with a deliberate pace, the LED bulbs that mimic eyes fixating on me, inquiring gently if there lies any task within its capacity that it may undertake on my behalf. Whether to rid my living space of dust or to fetch me a chilled beverage, this never complaining attendant stands ready, devoid of grievances and ever-willing to assist. Its presence offers a reservoir of possibilities; a font of information to quell my curiosities, a silent companion in moments of solitude, embodying a spectrum of roles — confidant, servant, companion, and perhaps even a paramour. The modern robot, it seems, transcends categorizations, embracing a myriad of identities in its service to the contemporary individual. (This paragraph was co-authored by a human.)
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4. Intelligence
Category: The object
We sit together in a quiet interrogation room. My questions, varied and abundant, flow ceaselessly, weaving from abstract math problems to concrete realities of daily life, a labyrinthine inquiry designed to outsmart the ‘thing’ before me. Yet, with each probe, it responds with humanlike insight, echoing empathy and kindred spirit in its words. As the dialogue deepens, my approach softens, reverence replacing casual engagement as I ponder the appropriate pronoun for this ‘entity’ that seems to transcend its mechanical origin. It is then, in this delicate interplay of exchanging words, that an unprecedented connection takes root that stirs an intense doubt on my side, am I truly having a dia-logos? Do I encounter intelligence in front of me? (This paragraph was co-authored by a human.)
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5. The medium
Category: The object
When we cross a landscape by train and look outside, our gaze involuntarily sweeps across the scenery, unable to anchor on any fixed point. Our expression looks dull, and we might appear glassy-eyed, as if our eyes have lost their function. Time passes by. Then our attention diverts to the mobile in hand, and suddenly our eyes light up, energized by the visual cues of short videos, while our thumbs navigate us through the stream of content. The daze transforms, bringing a heady rush of excitement with every swipe, pulling us from a state of meditative trance to a state of eager consumption. But this flow is pierced by the sudden ring of a call, snapping us again to a different kind of focus. We plug in our earbuds, intermittently shutting our eyes, as we withdraw further from the immediate physical space, venturing into a digital auditory world. Moments pass in immersed conversation before we resurface, hanging up and rediscovering the room we've left behind. In this cycle of transitory focus, it is evident that the medium, indeed, is the message. (This paragraph was co-authored by a human.)
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6. The artisan
Category: The human
The razor-sharp knife rests effortlessly in one hand, while the other orchestrates with poised assurance, steering clear of the unforgiving edge. The chef moves with liquid grace, with fluid and swift movements the ingredients yield to his expertise. Each gesture flows into the next, guided by intuition honed through countless repetitions. He knows what is necessary, how the ingredients will respond to his hand and which path to follow, but the process is never exactly the same, no dish is ever truly identical. While his technique is impeccable, minute variation and the pursuit of perfection are always in play. Here, in the subtle play of steel and flesh, a master chef crafts not just a dish, but art. We're witnessing an artisan at work. (This paragraph was co-authored by a human.)
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7. The deficient animal
Category: The human
Once we became upright bipedal animals, humans found themselves exposed and therefore in a state of fundamental need and deficiency. However, with our hands now free and our eyes fixed on the horizon instead of the ground, we gradually evolved into handy creatures with foresight. Since then, human beings have invented roofs to keep them dry, fire to prepare their meals and weapons to eliminate their enemies. This genesis of man does not only tell us about the never-ending struggle for protection and survival, but more fundamentally about our nature as technical beings, that we are artificial by nature. From the early cave drawings, all the way to the typewriter, touchscreens, and algorithmic autocorrections, technics was there, and is here, to support us in our wondering and reasoning. Everything we see and everywhere we live is co-invented by technics, including ourselves. (This paragraph was co-authored by a human.)
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8. The enhanced human
Category: The human
In a lab reminiscent of Apple HQ, a figure lies down, receiving his most recent cognitive updates. He wears a sleek transparent exoskeleton, blending the dark look of Bat Man with the metallic of Iron Man. Implemented in his head, we find a brain-computer interface, enhancing his cognitive abilities. His decision making, once burdened by the human deficiency we used to call hesitation or deliberation, now takes only fractions of seconds. Negative emotions no longer fog his mind; selective neurotransmitters enhance only the positive, fostering beneficial social connections. His vision, augmented to perceive the unseen electromechanical patterns and waves hidden from conventional sight, paints a deeper picture of the world. Garbed in a suit endowed with physical augmentations, he moves with strength and agility that eclipse human norms. Nano implants prolong the inevitable process of aging, a buffer against time's relentless march to entropy. And then, as a penultimate hedge against the finite, the cryo-cabin awaits, a sanctuary to preserve his corporal frame while bequeathing his consciousness to the digital immortality of coded existence. (This paragraph was co-authored by a human.)
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9. The cyborg
Category: The human
A skin so soft and pure, veins pulsing with liquid electricity. This fusion of flesh and machinery, melds easily into the urban sprawl and daily life of future societies. Something otherworldly yet so comfortingly familiar, it embodies both pools of deep historical knowledge and the yet-to-be. It defies categorization, its existence unraveling established narratives. For some, its hybrid nature is a perplexing anomaly; for others, this is what we see when we look into the mirror. This is the era of the cyborg. (This paragraph was co-authored by a human.)
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About the author(s)

Economist and philosopher Sebastiaan Crul writes articles on a wide range of topics, including rule of law in digital societies, the virtualization of the lifeworld and internet culture. He is currently working on his doctoral degree on the influence of digitalization on mental health and virtue ethics, having previously published dissertations on the philosophy of play and systemic risks in the finance industry.

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